We proposed a hybrid tilted fiber gratings (polarizing grating and tilted fiber Bragg grating)-based surface plasmon resonance (SPR) sensor. The hybrid tilted fiber grating, consisting of a polarizing grating and tilted fiber Bragg grating (TFBG), is fabricated in a single-mode fiber in series by using a UV-inscription technique, in which the TFBG could generate a dense cladding mode resonance to excite SPR and the polarizing grating could filter out the S-polarization cladding mode of the TFBG. Such proposed hybrid tilted fiber gratings could greatly simplify the interrogation system of the TFBG-based SPR sensor. The experiment results showed that the hybrid tilted fiber gratings-based SPR sensor has the refractive index sensitivity of 522.8 nm/RIU. Finally, by using the proposed sensor, we have achieved the hemoglobin concentration detection within a sensing range from 0.1 mg/mL to 1.0 mg/mL and the sensitivity of 8.144 nm/(mg/mL).